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Your endocannabinoid system responds to the endocannabinoids that your body produces and to the external cannabinoids found in the cannabis plant called phytocannabinoid cannabidiol or CBD. 

Therefore, it’s said that CBD helps reduce the symptoms of several different medical conditions, such as multiple sclerosis, epilepsy, depression, opioid withdrawal, anxiety, chronic pain and inflammation, and rheumatoid arthritis.

When CBD enters your body, it reacts with the CB1 and CB2 receptors found throughout your body to create several positive outcomes. CBD doesn’t bind directly to CB1 and CB2 receptors. Instead, How CBD Affects these two receptors is indirect.

The indirect actions include:

  • Activating TRPV1 receptors to control key functions, such as:
    • Pain perception
    • Body temperature
    • Inflammation 
  • Increases the amount of Anandamide in your body, which is responsible for motivation and pleasure. 
  • Stimulates the endocannabinoid system to promote homeostasis or balance, reduce pain sensations, and decrease inflammation. 

However, CBD doesn’t just affect the receptors, but it also indirectly affects the endocannabinoid system. 

How CBD Affects Humans - Infographic (1)

The Indirect Effects of CBD on Your Endocannabinoid System

CBD modifies the activity of the enzymes found in the endocannabinoid system and transports proteins. This increases the concentration of the default endocannabinoid, Anandamide. 

Enzymes – After the endocannabinoids bind to the cannabinoid receptors, it’s the enzymes that turn to break them down and stop them from overcorrecting. The two major enzymes to know are the FAAH enzymes, which break down Anandamide and MAGL enzymes, which break down the 2-AG endocannabinoids.

The key enzyme in your endocannabinoid system is the Fatty Acid Amide Hydrolase (FAAH). FAAH breaks down or metabolizes Anandamide, causing its concentration in the system to increase and with it, its impact. 

CBD magnifies the effects of this element. Monoacyglycerol lipase (MAGL) break downs 2-AG endocannabinoids, which are associated with your emotional state and prevent seizures and maintain cardiovascular health. Fatty acid-binding protein (FABP) depicts the vast effects of CBD. 

This protein binds to the Anandamide to transport it from the synapse to the outside, so FAAH can break it down. CBD decreases the amount of Anandamide metabolized and allows it to remain in the system for a longer duration, which, in return, enhances its effects. 

Other Therapeutic Benefits of CBD

Other ways of How CBD Effects Humans and exerts therapeutic benefits include:

  • 5-ht 1A Activation at High Doses – The receptors moderate addiction, anxiety, sleep, pain perception, nausea, vomiting, and appetite.
  • Adenosine Enhancement – CBD prevents adenosine reuptake, such as caffeine via equilibrate nucleoside transporter 1 (ENT1) inhibition, hence, this explains how CBD reduces inflammation and the symptoms of autoimmune medical conditions.
  • Dopamine D2 Receptor Binding – Most anti-psychotic prescription medications target the D2 receptor, hence, this explains the benefits of CBD in managing schizophrenia.
  • Glycine Receptor Potentiation – The receptors play a vital role in pain perception and CBD increases the effects of these receptors, which explains CBD’s ability to reduce chronic pain and inflammation.
  • GPR55 Antagonization – The brain contains several GPR55 receptors. The receptors stimulate the production of cancer cells when activated, whereas CBD deactivates them. This explains CBD’s role in reducing high blood pressure and alleviating the symptoms of osteoporosis. 
  • PPAR-gamma Activation – The nuclei of your body’s cells have PPAR-gamma receptors. They aid in the removal of the beta-amyloid plaque, which is the primary contributor to Alzheimer’s Disease. This function also explains why CBD may benefit people diagnosed with diabetes and schizophrenia. 
  • TRPV1 Activation – TRPV1 receptors regulate body temperature, inflammation, and pain. 

How the Endocannabinoid System Works?

A perfectly functioning endocannabinoid system ensures balance and harmony in your tissues, cells, and organs. Here’s how a functioning and balanced endocannabinoid system works:

  1. The ECS requires dietary and nutritional co-factors as building blocks to function optimally.
  2. A functioning ECS produces endocannabinoids, based on your body’s demand and needs.
  3. Once created, the endocannabinoids interact with ECS receptor sites. 
  4. Once activated, it causes the release of neurotransmitters to deliver messages to tissues, organs, cells, and other systems of the body to restore balance. 
  5. The body may enzymatically degrade endocannabinoids when required and based on the body’s needs to maintain a continuous ECS balance.

Some people may experience Clinical Endocannabinoid Deficiency (CECD). It’s a recognized medical diagnosis where a person doesn’t produce enough of cannabinoids. CECD is said to play a vital role in a wide range of medical conditions such as:

  • Chronic Anxiety
  • Chronic Pain
  • Depression
  • Fibromyalgia
  • Inflammation
  • Parkinson’s Disease
  • Post-traumatic Stress Disorder (PTSD)
  • Psoriasis
  • Schizophrenia
  • Substance Abuse
  • And More

This is where CBD comes in. 

How CBD Affects Humans - Infographic

The Function of CBD in Restoring the Balance of the Endocannabinoid System

CBD is an effective method to treat CECD. According to researchers, CBD prevents the enzyme Fatty Acid Amide Hydrolase (FAAH) from breaking down and reusing endocannabinoids. The method to correct the balance of an imbalanced endocannabinoid system due to a medical condition is CBD.

CBD interacts with and binds to both CB1 and CB2 receptors in the brain. This alleviates medical conditions, such as anxiety, pain, inflammation, and muscle spasms. You also will not experience a “high” on CBD. Some specific medical conditions CBD treats include inflammation, seizures, psychosis, inflammatory, bowel disease, migraines depression, anxiety, pain, muscle spasticity, low appetite due to cancer or medical treatment, and vomiting and nausea.

Different Ways to Use CBD

If you want to use CBD to restore the balance of your endocannabinoid system, you can choose the consumption method that best suits you. You can take CBD orally by adding it food or in edible form, supplement, gel, liquid, and tincture. 

You can take CBD topically by rubbing lotion, oil, or extract on the site of pain. You can inhale CBD through vapor, spray, or smoke. Since determining the correct dose of CBD is not easy, you may want to use more than one method at the same time to determine the dose that works best for you. 

You can use just one method of consuming CBD, increasing its dose gradually until you find the correct dose. Even though you can’t overdose on CBD, you still should not take more CBD than necessary. Before you take CBD for the treatment of a medical condition, ask your doctor and also find out if it is legal in your state. 

The views and opinions expressed in this blog are those of the authors and do not necessarily reflect the official policy or position of ShowGrow or any other agency.

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